Manage Your Weight with Sublingual Medication
The usage of GLP-1 receptor agonists has increased significantly worldwide. This class of medication includes various injectable and oral options, such as Semaglutide. Due to high demand, these medications have been added to the FDA’s Drug Shortage List. As a result, the FDA has issued guidance for compounding pharmacies to help address the shortage by making essential copies of the patented drugs, for as long as the drugs remain on the FDA’s Shortage List.
Compounded Semaglutide is available at Potter’s House Apothecary in both injectable and sublingual forms. Many patients and their healthcare providers would prefer to avoid injections if possible due to the challenges associated with giving/receiving an injection, the complex storage conditions requiring freezing/refrigeration, and the short expiration dating per USP guidelines. Patients also report suffering from side effects like intense nausea and headaches. This feedback has led us to explore alternatives to the injectable medications we compound here at Potter’s House Apothecary.
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GLP-1 receptor agonists work by increasing the amount of insulin that the pancreas releases in response to food, while decreasing the amount of sugar the liver releases into the blood and slowing food leaving the stomach after eating. In turn, this helps control blood glucose levels and prompts the feeling of fullness, resulting in weight loss overtime. These medications are intended to work in conjunction with diet and exercise to improve blood sugar (glucose) levels in adults with type 2 diabetes mellitus. GLP-1 medications are not for use in patients with type 1 diabetes.
The oral route of administration for Semaglutide does pose challenges due to the drug’s high molecular weight, extremely low absorption with the commercially available oral tablets, and the drug’s sensitivity to the heat required to compound it into a lozenge. As compounders, we specialize in the sublingual delivery of medications for hormone replacement therapy and pediatrics. We are pleased to offer a patent-pending compounded formulation of Semaglutide for sublingual administration.
The sublingual suspension (liquid) is made using both commercially available and bulk ingredients, and SubMagna™ HMW anhydrous base. SubMagna™ is an anhydrous, self-emulsifying drug delivery system that is specifically designed to deliver drugs with a high molecular weight and has beneficial mucoadherant properties to increase contact time with the sublingual space. The medication is absorbed into the bloodstream through the mucosa underneath the tongue. Some of the medication may also be absorbed in the GI tract and stomach after swallowing.
The sublingual suspension is dispensed in a bottle with an oral syringe for accurate dosing. You simply use the syringe to draw the pre-measured amount of the medication out of the bottle. Place and hold the medication under your tongue for 90 seconds, then swallow the remaining liquid. This is done once a day, you should avoid food, drink, or other medications/supplements for at least 30 minutes before and after administration. The medication does not require refrigeration or freezing and is good for up to 90 days.
To obtain Compounded Semaglutide, you'll need a prescription from your healthcare provider. Your provider can call in, fax, or send your prescription electronically. Once we receive your prescription, we’ll reach out to you with pricing and delivery options. If you need a referral for a weight management provider, please see our list of providers.
Weight Management Provider Resource ListTrust is key when you are working with a compounding pharmacy to provide your medication. In addition to our voluntary PCAB Accreditation, our pharmacy is USP 795, 797, and 800 compliant. We use high-quality ingredients (from FDA-inspected facilities) and leverage state-of-the-art technology to produce medications that meet your healthcare provider’s exact specifications. You will have peace of mind knowing that your medication has been compounded by a trusted pharmacy professional and is not only safe, but effective.
Prescribers - Request Info HerePotter’s House Apothecary specializes in sterile and non-sterile compounding services. We also provide educational webinars, private consultations and pharmaceutical grade nutritional supplements.
Monday - Friday: 8:00am - 6:00pm
Saturday & Sunday: Closed
A prescription from a licensed practitioner is required for compounded medications. The FDA does not review any compounded medication for safety or efficacy. This is the primary reason that we encourage any patient or healthcare provider looking to compounding as a treatment option to always engage a PCAB Accredited Compounding Pharmacy.
